Blar i forfatter "Hemez, Colin"

Viser treff 1-2 av 2

    • High rifampicin peak plasma concentrations accelerate the slow phase of bacterial decline in tuberculosis patients: Evidence for heteroresistance 

      Martinecz, Antal; Boeree, Martin J.; Diacon, Andreas H.; Dawson, Rodney; Hemez, Colin; Arnoutse, Rob; Abel zur Wiesch, Pia (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-13)
      Background - Antibiotic treatments are often associated with a late slowdown in bacterial killing. This separates the killing of bacteria into at least two distinct phases: a quick phase followed by a slower phase, the latter of which is linked to treatment success. Current mechanistic explanations for the in vitro slowdown are either antibiotic persistence or heteroresistance. Persistence is defined ...

    • Mechanisms of antibiotic action shape the fitness landscapes of resistance mutations 

      Hemez, Colin; Clarelli, Fabrizio; Palmer, Adam C.; Bleis, Christina; Abel, Sören; Chindelevitch, Leonid; Cohen, Theodore; Abel zur Wiesch, Pia (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-24)
      Antibiotic-resistant pathogens are a major public health threat. A deeper understanding of how an antibiotic’s mechanism of action influences the emergence of resistance would aid in the design of new drugs and help to preserve the effectiveness of existing ones. To this end, we developed a model that links bacterial population dynamics with antibiotic-target binding kinetics. Our approach allows ...